| Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
| marA |
BacMet ID: BAC0560Code for:
RegulatorFamily: Contains 1 HTH araC/xylS-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]Description: A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.Length (amino acid):
127Reference: Asako et al. 1997; Pubmed- 9097440
| Similar
resistance genes in 'BacMet Predicted database' |
| marR |
BacMet ID: BAC0561Code for:
RegulatorFamily: Contains 1 HTH marR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]Description: Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.Length (amino acid):
144Reference: Asako et al. 1997; Pubmed- 9097440
| Similar
resistance genes in 'BacMet Predicted database' |
| robA |
BacMet ID: BAC0334Code for:
Binding proteinFamily: 1 HTH araC/xylS-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli O157:H7Location:
ChromosomeCompound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.Length (amino acid):
289Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315
| Similar
resistance genes in 'BacMet Predicted database' |
